期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 23, 页码 6641-6645出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201702745
关键词
asymmetric allylation; cascade reaction; C-H activation; chiral indoline; sulfoxide-oxazoline
资金
- NSFC [21502183]
- Chinese Academy of Science [XDB20020000]
A chiral PdII-catalyzed cascade sp(2) C-H functionalization/intramolecular asymmetric allylation reaction is reported. A new chiral sulfoxide-oxazoline (SOX) ligand bearing single chiral center on the sulfur was identified as the optimal ligand for the reaction, being efficient both in the C-H cleavage step and the stereocontrol of the allylation step. The broad scope of this method with respect to aryl ureas and 1,3-dienes enables the rapid construction of valuable chiral indoline derivatives with high yields and enantioselectivities (up to 99% yield, up to 95:5 e.r.).
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