期刊
ANTIOXIDANTS
卷 6, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox6020042
关键词
angiogenesis; NOX4; TRX2; ROS
资金
- National Key Research and Development Program of China [2016YFC1300600]
- National Natural Science Foundation of China [91539110]
- Scientific Grants of Guangdong [2015B020225002, 2015A050502018, R01 HL109420, R01 HL115148]
- Connecticut Stem Cell Innovation Award [14-SCB-YALE-17]
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H2O2 in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases.
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