期刊
ANALYTICAL CHEMISTRY
卷 89, 期 11, 页码 6107-6113出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b00824
关键词
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资金
- National Natural Science Foundation of China [21472066, 21672080]
- Natural Science Foundation of Hubei Province [2014CFA042]
- CCNU from the colleges' basic research and operation of MOE [CCNU16A02028, CCNU16JCCZX02]
Selenocysteine (Sec) is the 21st naturally occurring amino acid and has emerged as an important sensing target in recent years. However, fluorescent detection of Sec in living systems is challenging. To date, very few fluorescent Sec probes have been reported and most of them respond fluorescence to Sec in the-visible region. In this paper, a very promising near-infrared fluorescent probe for Sec was developed. This probe works in aqueous solution over a wide pH range under mild conditions and can be used for rapid; highly selective and sensitive detection of Sec with significant near-infrared fluorescent turn-on signal changes. In addition, it features a remarkable large Stokes shift (192 nm) and a low detection limit (60 nM) for Sec with a wide linear range (0-70 mu M). Moreover, this probe can be conveniently used to detect Sec in serum samples, living cells, and animals, indicating it holds great promise for biological applications.
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