期刊
CANCER
卷 123, 期 -, 页码 2154-2162出版社
WILEY
DOI: 10.1002/cncr.30491
关键词
immunotherapy; tumor-infiltrating lymphocytes; adoptive cellular immunotherapy; T cell receptor; chimeric antigen receptor; melanoma
类别
The therapeutic potential of adoptive cell therapy (ACT) in cancer patients was first acknowledged 3 decades ago, but it was an esoteric approach at the time. In recent years, technological advancements have transformed ACT into a viable therapeutic option that can be curative in some patients. In fact, current ACT response rates are 80% to 90% for hematological malignancies and 30% for metastatic melanoma refractory to multiple lines of therapy. Although these results are encouraging, there is still much to be done to fulfill ACT's potential, specifically with regard to improving clinical efficacy, expanding clinical indications, reducing toxicity, and increasing production and cost-effectiveness. This review addresses the current major obstacles to ACT and presents potential solutions. (c) 2017 American Cancer Society.
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