期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-15825-4
关键词
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资金
- Japan Society for the Promotion of Science KAKENHI [23390225, 26461224]
- Integration Research for Agriculture and Interdisciplinary Fields from the National Agriculture and Food Research Organization
- Japan Agency for Medical Research and Development [15652238]
- Mitsubishi Tanabe Pharma Corporation
- Grants-in-Aid for Scientific Research [17K09697, 15K09268, 17H01566, 16K15469, 17K16079, 17K09706, 26461224, 23390225] Funding Source: KAKEN
Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 knockout (KO) and wild-type (WT) mice with high fat diet (HFD) or cold exposure. Under normal diet, physical constitutions of Lcn2 KO and WT mice were indistinguishable. During HFD treatment, Lcn2 KO mice exhibited larger brown adipose tissues (BAT), consumed more oxygen, ate more food and gained less body weights as compared to WT mice. When exposed to 4 degrees C, KO mice showed higher body temperature and more intense F-18-fluorodeoxyglucose uptake in BAT, which were cancelled by beta 3 adrenergic receptor blocker or iron-loaded (but not iron-free) LCN2 administration. These findings suggest that circulating LCN2 possesses obesity-promoting and anti-thermogenic effects through inhibition of BAT activity in an iron-dependent manner.
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