期刊
CANCER
卷 123, 期 -, 页码 2089-2103出版社
WILEY
DOI: 10.1002/cncr.30684
关键词
carcinogen; genetically engineered mice; melanoma; mouse models; ultraviolet (UV) radiation
类别
资金
- National Institutes of Health (NIH)/National Cancer Institute (NCI)
- NIH/NCI [K22CA163799, R01CA193711]
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. (c) 2017 American Cancer Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据