期刊
PROGRESS IN BIOMATERIALS
卷 6, 期 1-2, 页码 13-26出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s40204-017-0064-z
关键词
Chemotherapy; Drug delivery systems; Kinase inhibitors; Skin cancer therapy; Topical delivery
资金
- CAPES foundation, Brazilian Ministry of Education-Brazil [13543/13-0]
- FEDER funds through the Competitivity Factors Operational Programme-COMPETE
- national funds through FCT-Foundation for Science and Technology [POCI-01-0145-FEDER-007136]
- Singapore National Research Foundation [NMRC/TCR/008-SERI/2013]
- Singapore National Medical Research Council [NMRC/CBRG/0048/2013]
Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. This literature review intends to elucidate the possibilities to treat melanoma skin cancer using hybrid nanofibers developed by advanced electrospinning process. In this review we have shown that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells. Inhibitors of protein kinase are already available in the market for melanoma treatment and are approved by the FDA; these agents are cobimetinib, dabrafenib, ipilimumab, nivolumab, trametinib, and vemurafenib. We also report a case study involving two different approaches for targeting melanoma skin cancer therapy, namely, magnetic-based core-shell particles and electrospun mats.
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