期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 22, 页码 18423-18428出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b03905
关键词
nanomaterials; peptide; circulating tumor cells; HER2; cancer metastasis
资金
- National Natural Science Foundation of China [21273051, 31600803]
- Natural Science Foundation of Beijing Municipality [2162044]
- Chinese Academy of Sciences [XDA09030306]
- CAS Key Laboratory of Standardization and Measurement for Nano technology
- Key Laboratory for Biological Effects of Nanomaterials and Nanosafety
The detection of Circulating tumor cells (CTCs) with a specific antigen expression is necessary in therapeutic response monitoring and targeted therapy guidance. The existence of human epidermal growth factor receptor 2 (HER2) and the concentration of HER2-positive CTCs are Strong indicators for patient diagnosis, prognosis, and therapeutic monitoring Herein we report the direct isolation of HER2-positive CTCs by peptide-functionalized nanomaterials. We designed and screened out a peptide as an HER2 antibody alternative demonstrating high HER2 affinity and selectivity This HER2 recognition peptide bound efficiently with HER2 at the ligand-binding domain. Efficient HER2-positive CTC capture and detection were demonstrated using magnetic nanoparticles functionalized with the HER2 recognition peptide.
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