期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 22, 页码 19248-19257出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b04810
关键词
MOF; drug delivery; antibacterial; biocompatibility; osteogenic differentiation
资金
- National Natural Science Foundation of China [51422102, 81271715]
- National Key Research and Development Program of China [2016YFC1100600, 2016YFC1100604]
- Shenzhen Peacock Program [1108110035863317]
Sustained drug release plays a critical role in targeting the therapy of local diseases such as bacterial infections. In the present work, porous iron-carboxylate metal-organic framework [MOF-53(Fe)] nanoparticles (NPs) were designed to entrap the vancomycin (Van) drugs. This system exhibited excellent chemical stability under acidic conditions (pH 7.4, 6.5, and 5.5) and much higher drug-loading capability because of the high porosity and large surface area of MOF NPs. The results showed that the drug-loading ratio of Van could reach 20 wt % and that the antibacterial ratio of the MOF-53(Fe)/Van system against Staphylococcus aureus could reach up to 90%. In addition, this MOF-53(Fe)/Van system exhibited excellent biocompatibility because of its chemical stability and sustained release of iron ions. Hence, these porous MOF NPs are a promising bioplatform not only for local therapy of bacterial infections but also for other biomedical therapies for tissue regeneration.
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