期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 32, 页码 7677-7681出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201701627
关键词
cross-coupling; decarboxylation; nickel; photoredox catalysis; sulfoxaflor
Metallaphotoredox cross-coupling reactions have recently emerged as a powerful tool for the construction of C(sp(2))-C(sp(3)) bonds between alkyl chains and aromatic systems, including electron-deficient heteroaryls, which are known to be challenging coupling partners. In this article, we disclose the Ni/Ir-catalyzed photoredox de-carboxylative coupling of readily available S-substituted thiolactic acids with electron-deficient heteroaryl bromides, which resulted in the formation of simple but otherwise not easily accessible heteroarenes with alkylsulfide side chains. To demonstrate a practical use of this coupling reaction, we have shown its efficiency in the one-step synthesis of a key intermediate in the synthesis of the recently marketed insecticide Sulfoxaflor, and for the short synthesis of SF5-Sulfoxaflor.
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