Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance

The emergence of drugresistant bacteria, severely challenges the antimicrobial agents and antibacterial strategy. Here, we demonstrate a novel simple, arid highly efficient combination therapy strategy by direct combinations of cationic conjugated polymert (CCPs) with,pOlypepticle antibiotics against Gram-negative: and Gram-positive bacteria based on a synergistic antibacterial effect. The combination therapy method enhances the antibacterial efficacy with a significantly reduced antibiotic dosage. Also, the highly efficient and synergistic killing of drug-resistant bacteria is realized. Using combinations of CCPs and antibiotics to show increased antibacterial activity, this strategy will provide a much wider scope of the than that of antibioticantibiotic combinations. The proposed combination therapy platform for the treatment of pathogens in particular the drug-resistant bacteria and of efficient antibacterial systems. discovery of efficient antibacterial systems method provides a universal and powerful also opens a new way for the development of efficient antibacterial systems.