期刊
RSC ADVANCES
卷 7, 期 56, 页码 35086-35095出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra06119f
关键词
-
资金
- National Natural Science Foundation of China [21506096, 81603290, 51603101]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [16KJB350001]
- National High Technology Research and Development Program of China [2013AA020302]
- National Key Research & Development Plan of China [2016YFC1201500]
A mono approach to cancer therapy usually fails to achieve satisfactory results due to its limited killing effect. Nanostructured lipid carriers (NLCs) with high biocompatibility as well as tumor targetability were successfully designed and formulated in our study to co-deliver paclitaxel (PTX) and indocyanine green (ICG) for combined chemo and photodynamic therapy. ICG not only acted as an imaging reagent but also as a laser responsive agent to aid accelerated drug release under laser irritation. It has been demonstrated that our drug delivery system (DDS) not only significantly enhanced the stability of drugs, produced sufficient local ROS and triggered accelerated drug release upon laser irradiation, but also increased intracellular uptake of drugs and induced increased cytotoxicity in cancer cells via synergistic effects. Moreover, NLCs demonstrated excellent tumor targetability in tumor-bearing mice. Therefore, tumor targeted co-delivery of PTX and ICG mediated by NLCs could be a promising approach for further development as an effective strategy for cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据