期刊
RSC ADVANCES
卷 7, 期 17, 页码 10143-10149出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra28228h
关键词
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资金
- National Natural Scientific Foundation of China [51372125, 51572136, 21571112]
- China Postdoctoral Science Foundation [2015M570368]
- Natural Science Foundation of Shandong Province, China [ZR2016BQ28]
- Scientific Research Foundation of Qingdao University of Science and Technology
The application of functional nanomaterials in cancer therapy has become a new developing trend due of their unique size-dependent physicochemical performance. In this study, CuS nanoprisms were fabricated via a seed-mediated growth method. The as-prepared CuS nanoprisms possessed a more intense near-infrared absorption at 1184 nm compared with other morphologies. CuS nanoprisms were modified with a polypyrrole (PPy) shell on the surface through oxidative polymerization. The PPy shell efficiently decreased the nanocomposite cytotoxicity and increased the biocompatibility. Based on the excellent photothermal conversion performance of CuS-PPy nanoprisms, the cancer cells in vitro could be killed effectively and the tumor in vivo could be cured through photothermal therapy. This indicated that CuSPPy nanoprisms are able to be used as an efficient theranostic agent for tumor photothermal therapy in the future.
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