期刊
AMERICAN JOURNAL OF NEURORADIOLOGY
卷 38, 期 5, 页码 961-965出版社
AMER SOC NEURORADIOLOGY
DOI: 10.3174/ajnr.A5133
关键词
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资金
- National Institutes of Health [R01AG10161, R01AG40039]
- National Alzheimer's Coordinating Center Junior Investigator Award
- ASNR Foundation Alzheimer's Imaging Research Grant Program
- RSNA Resident/Scholar Award
- National Institutes of Health/National Institute on Drug Abuse grant [U24DA041123]
- National Institute for Biomedical Imaging and Bioengineering [P41EB015896, R01E8006758, R21EB018907, R01EB019956]
- National Institute on Aging [5R01AG008122, R01AG016495]
- National Institute for Neurological Disorders and Stroke [R01NS0525851, R21NS072652, R01NS070963, R01NS083534, 5U01NS086625]
- Shared Instrumentation Grants [1S10RR023401, 1S10RR019307, 1S10RR023043]
- National Institutes of Health Blueprint for Neuroscience Research, part of the multi-institutional Human Connectome Project [5U01-MH093765]
BACKGROUND AND PURPOSE: The entorhinal cortex, a critical gateway between the neocortex and hippocampus, is one of the earliest regions affected by Alzheimer disease associated neurofibrillary tangle pathology. Although our prior work has automatically delineated an MR imaging based measure of the entorhinal cortex, whether antemortem entorhinal cortex thickness is associated with postmortem tangle burden within the entorhinal cortex is still unknown. Our objective was to evaluate the relationship between antemortem MRI measures of entorhinal cortex thickness and postmortem neuropathological measures. MATERIALS AND METHODS: We evaluated 50 participants from the Rush Memory and Aging Project with antemortem structural Tl-weighted MR imaging and postmortem neuropathologic assessments. Here, we focused on thickness within the entorhinal cortex as anatomically defined by our previously developed MR imaging parcellation system (Desikan-Killiany Atlas in FreeSurfer). Using linear regression, we evaluated the association between entorhinal cortex thickness and tangles and amyloid-beta load within the entorhinal cortex and medial temporal and neocortical regions. RESULTS: We found a significant relationship between antemortem entorhinal cortex thickness and entorhinal cortex (P = .006) and medial temporal lobe tangles (P = .002); we found no relationship between entorhinal cortex thickness and entorhinal cortex (P = .09) and medial temporal lobe amyloid-P (P = .09). We also found a significant association between entorhinal cortex thickness and cortical tangles (P = .003) and amyloid-beta (P = .01). We found no relationship between parahippocampal gyrus thickness and entorhinal cortex (P = .31) and medial temporal lobe tangles (P =.051). CONCLUSIONS: Our findings indicate that entorhinal cortex-associated in vivo cortical thinning may represent a marker of postmortem medial temporal and neocortical Alzheimer disease pathology.
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