期刊
RSC ADVANCES
卷 7, 期 26, 页码 15864-15876出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra01354j
关键词
-
资金
- Major State Basic Research Development Program of China 973 Program [2015CB932103]
Nanosystems often require different surface coatings to improve their biocompatibility, circulating time, the intracellular uptake and reduce toxic side effects. A preunderstanding and a simple controlling of the surface coatings' interactions with biological systems are of vital importance. Herein, we successfully modified model nanoparticles (NPs) with three surface modifiers: bovine serum albumin (BSA), poly-L-lysine (PLL) and polyethylene glycol (PEG) simply and uniformly via polydopamine (pD). Following, the serum stability, drug release profile, pharmacokinetics, in vivo biodistribution and interactions with tumor cells of these modified nanoparticles were systematically evaluated for further applications. According to the in vitro and in vivo results, BSA coated NPs could inhibit the plasma proteins' adsorption thus prolong their circulation time to some extent. In addition, the BSA shell showed good biocompatibility, nontoxicity and a delayed drug release. Interestingly, PLL coated NPs exhibited higher and pHdependent intracellular uptake and antitumor activity in an acidic tumor micro environment. Nonetheless, the PLL coating did not exhibit particularly high toxicity due to its low positive charge density. PEG coated NPs displayed good pharmacokinetic profiles as expected. In the light of the successful application of the above pDsurface modifier compound shells (pDBSA, pDPLL, pDPEG), diverse particles can be modified to selectively optimize their nature and achieve the goal such as improved pharmacokinetic profiles, enhanced cellular internalization ability and lower toxicity. This strategy that can selectively alter the biological fate of NPs simply by tunable coatings provides great potential for controllable drug delivery systems for cancer and other therapeutic or diagnostic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据