期刊
RSC ADVANCES
卷 7, 期 81, 页码 51062-51068出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra11305f
关键词
-
资金
- Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme (FRGS)
An efficient and highly selective multicomponent synthesis of 4-aminoimidazo[1,2-a][1,3,5]triazines, which are 5-aza-7-deaza-isosteres of adenine, was developed. The reaction of 2-aminoimidazoles, triethyl orthoformate and cyanamide under microwave irradiation proceeded regioselectively to provide a library of novel 5-aza-7-deaza-adenines in good yields and purity. The developed method was demonstrated to be scalable and highly reproducible in three different monomode microwave reactors. A rearrangement was proposed to explain the high selectivity of the reaction.
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