期刊
RSC ADVANCES
卷 7, 期 20, 页码 11880-11889出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra27669e
关键词
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资金
- Science and Technology Projects of Shenzhen [JCYJ20140417113430596, CXZZ20140417 113430716]
- Science and Technology project of Guangdong Province [2015A010105021]
- Youth Talents of Guangdong Science and Technology Innovation [2015TQ01X076]
- Shenzhen Peacock Innovation Team [110811003586331]
Composite scaffolds of type 13-93 bioactive glass (13-93 BG) and sodium alginate (SA), denoted 13-93 BG/ SA, in mass ratios of 0 : 4, 1 : 4, 2 : 4 and 4 : 4 were prepared for bone regeneration by 3D printing under mild conditions. All obtained scaffolds were completely interconnected. As the 13-93 BG/SA mass ratio increased from 0 : 4 to 4 : 4, the pore size improved from 340 +/- 27 to 530 +/- 27 mu m, porosity increased from 65.5 + 5.3 to 87.5 + 3.9% and shrinkage ratios decreased by half. Moreover, 13-93 BG incorporation improved the compressive strength and modulus of the SA scaffold, achieving highest values of 16.74 +/- 1.78 MPa and 79.49 +/- 7.38 MPa, respectively, in 13-93 BG/ SA with a 2 : 4 mass ratio. Furthermore, in vitro apatite mineralization, the release of bioactive ions (Mg2+ and SiO44 ) and a weakly alkaline pH were exhibited by scaffolds containing 13-93 BG, which further promoted the attachment, proliferation and osteogenic differentiation of rBMSCs on composite scaffolds. As a result, 3D-printed 13-93 BG/ SA scaffold was an ideal candidate for bone regeneration.
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