期刊
COMPREHENSIVE PHYSIOLOGY
卷 7, 期 2, 页码 623-634出版社
WILEY
DOI: 10.1002/cphy.c160013
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资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico, FONDECYT, Chile [3160226, 1161156, 1130250, 11150282]
- FONDAP [15130011]
- PAI Insertion Program [79150007]
- CONICYT
Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ubiquitous nature, the regulation of both is deeply intertwined, whereby Ca2+ regulates mitochondrial functions, while mitochondria shape Ca2+ dynamics. Deregulation of either Ca2+ or mitochondrial signaling leads to abnormal function, cell damage or even cell death, thereby contributing to muscle dysfunction or cardiac pathologies. Moreover, altered mitochondrial Ca2+ homeostasis has been linked to metabolic diseases like cancer, obesity, and pulmonary hypertension. In this review article, we summarize the mechanisms that coordinate mitochondrial and Ca2+ responses and how they affect human health. (C) 2017 American Physiological Society.
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