期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 25, 页码 7252-7256出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703674
关键词
cross-coupling; cyclization; dearomatization; heterocycles; palladium
资金
- National Key RAMP
- D Program of China [2016YFA0202900]
- National Basic Research Program of China [2015CB856600]
- NSFC [21332009, 21361140373, 21421091]
- Program of Shanghai Subject Chief Scientist [16XD1404300]
- CAS [XDB20000000, QYZDY-SSW-SLH012]
A novel palladium(0)-catalyzed intermolecular arylative dearomatization of alpha-naphthols and subsequent aza-Michael reaction is described. Two adjacent stereocenters were constructed efficiently through consecutive arylative dearomatization and Michael addition reactions. By utilizing this method, structurally diverse benzomesembrine derivatives were synthesized with excellent yields and chemoselectivity. The benzomesembrine products were shown to undergo versatile functional-group transformations.
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