期刊
CARBOHYDRATE POLYMERS
卷 169, 期 -, 页码 480-494出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.04.032
关键词
Catechin; Dextran; Chitosan; Sodium alginate; Sodium periodate; NMR
资金
- Australian Research Council (ARC) [FT1201090]
In this contribution, we present a strategy to functionalise three natural carbohydrate polymers (dextran a neutral polymer, sodium alginate an anionic polymer and chitosan a cationic polymer) with catechin with excellent degrees of functionality. In a first step, the carbohydrate polymers were oxidised by sodium periodate to yield aldehyde functionalised carbohydrate polymers. The presence of aldehyde groups was exploited to attach catechin by an acid catalysed nucleophilic reaction. The degree of catechin functionalisation could be easily tuned by varying the acid concentration in the reaction mixture, achieving catechin functionalisation levels of up to 48% for dextran aldehyde catechin, 35% for chitosan-aldehyde-catechin and 22% for sodium alginate aldehyde catechin. H-1, H-1 C-13 HSQC and DOSY NMR were performed to elucidate the structural differences between the three aldehyde functionalised polysaccharides and how this affects their reactivity and conjugation behaviour. All three carbohydrate polymer-catechin conjugates showed superior free -radical scavenging activity compared with the non-functionalised polymers. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据