期刊
RSC ADVANCES
卷 7, 期 4, 页码 2081-2091出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25027k
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资金
- National Natural Science Foundation of China [21303170]
- Natural Science Foundation of Hubei Province [2015CFB187]
- Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) [CUGL150414, CUGL140413, CUG120115]
The development of high-performance adsorbents for efficient removal of bilirubin from albumin-rich solution is still a considerable challenge. In this study, a magnetic nitrogen-doped porous carbon (m-NpC) was facilely synthesized through a simple one-pot route using the biomass chitosan and the iron salt Fe(NO3)(3)center dot 9H(2)O as precursors, and NaCl as template agent, respectively. Intriguingly, the resulting m-NpC material showed a hierarchically micro-meso-macroporous structure, high surface area (289 m(2) g(-1)), large pore volume (0.33 cm(3) g(-1)), and good magnetic response. In particular, the basic site-rich surface of m-NpC obtained as a result of nitrogen doping could compete effectively with albumin for bilirubin binding. As such, the m-NpC was used as a magnetically separable bilirubin adsorbent and showed superior adsorption properties for bilirubin removal from a bovine serum albumin (BSA)-rich solution. Under optimized conditions, the maximum adsorption capacity of m-NpC was up to 72.4 mg g(-1), which is significantly higher than the value achieved by magnetic non-nitrogen doped porous carbon (24.7 mg g(-1)), but also superior to those of many previously reported adsorbents for BSA-boned bilirubin removal. Moreover, as evidenced by hemolysis assay, this material exhibited only a negligible hemolysis effect. These results suggest that the composite developed in this work can be used as a promising adsorbent in blood purification application to mitigate the risk of excess bilirubin.
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