期刊
RSC ADVANCES
卷 7, 期 9, 页码 5372-5380出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra27020d
关键词
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资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP CONICET 112-201101-00204]
- Universidad Nacional de Rio Cuarto
- Agencia Nacional de Promocion Cientifica y Tecnica [PICT 2012-0232, PICT 2015-0585]
- Ministerio de Ciencia y Tecnologia, gobierno de la provincia de Cordoba (PID)
- CONICET
We evaluate in vitro and in vivo toxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (AOT-BHD) in order to investigate their potential application as an oral drug delivery system. Unilamellar vesicles were spontaneously formed by dissolving AOT-BHD in water and their toxicity was evaluated through in vitro and in vivo assays. Cell membrane permeability assays (hemolytic activity, Trypan blue assay) and cellular survival or proliferation (MTT assay) were performed. The results showed that only the highest concentration of vesicles tested (2 mg mL(-1)) diminished the red blood cells' resistance. In vivo toxicity evaluation was carried out on mice through lethal dose 50 (LD50) experiments. The safety for living organisms in doses lower than 0.05 mg mL(-1) and the acid pH stability makes our AOT-BHD vesicles a very promising candidate for oral drug delivery.
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