期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 26, 期 17, 页码 986-999出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2016.6820
关键词
nitric oxide/NO; glioma; nitric oxide synthase/NOS; cancer stem cell; therapy
资金
- National Institutes of Health [R01 CA151522, R21 NS096531, P20 CA 151129]
- NIH [F31 CA200085]
- University of Alabama at Birmingham Department of Cell, Developmental and Integrative Biology
Significance: Gliomas are central nervous system tumors that primarily occur in the brain and arise from glial cells. Gliomas include the most common malignant brain tumor in adults known as grade IV astrocytoma, or glioblastoma (GBM). GBM is a deadly disease for which the most significant advances in treatment offer an improvement in survival of only similar to 2 months. Critical Issues: To develop novel treatments and improve patient outcomes, we and others have sought to determine the role of molecular signals in gliomas. Recent Advances: One signaling molecule that mediates important biologies in glioma is the free radical nitric oxide (NO). In glioma cells and the tumor microenvironment, NO is produced by three isoforms of nitric oxide synthase (NOS), NOS1, NOS2, and NOS3. NO and NOS affect glioma growth, invasion, angiogenesis, immunosuppression, differentiation state, and therapeutic resistance. Future Directions: These multifaceted effects of NO and NOS on gliomas both in vitro and in vivo suggest the potential of modulating the pathway for antiglioma patient therapies.
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