期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 23, 页码 19698-19705出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b05296
关键词
MOFs; naringin; mineralized collagen coating; controlled release; antibiosis; osteogenesis
资金
- National Natural Science Foundation of China [51502262, 81600838, 51472216, 51372217, 81670972, 81371120, 81501607]
- Medical Technology and Education of Zhejiang Province of China [2016KYB178]
- Zhejiang Provincial Natural Science Foundation [LY15E020004]
- Fundamental Research Funds for the Central Universities [2017XZZX008-05]
Two important goals in orthopedic implant research are to promote osseointegration and prevent infection. However, much previous effort has been focused on the design of coatings to either enhance osseointegration while ignoring antibacterial activity or vice versa, to prevent infection while ignoring bone integration. Here, we designed a multifunctional mineralized collagen coating on titanium with the aid of metal-organic framework (MOF) nanocrystals to control the release of naringin, a Chinese herbal medicine that could promote osseointegration and prevent bacterial infection. The attachment, proliferation, osteogenic differentiation, and mineralization of mesenchymal stem cells on the coating were significantly enhanced. Meanwhile, the antibacterial abilities against Staphylococcus aureus were also promoted. Furthermore, release kinetics analysis indicated that the synergistic effect of a primary burst release stage and secondary slow release stage played a critical role in the performance and could be controlled by the relative concentrations of MOF and naringin. This work thus provides a novel strategy to engineer multifunctional orthopedic coatings that can enhance osseointegration and simultaneously inhibit microbial cell growth.
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