期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 23, 页码 20150-20160出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b16425
关键词
poly(vinylpyrrolidone); hyaluronan; glycoprotein; friction; tears; ocular lubricants; perfluorophenyl azide
资金
- Johnson & Johnson Vision Care Inc.
Biomaterials used in the ocular environment should exhibit specific tribological behavior to avoid discomfort and stress-induced epithelial damage during blinking. In this study, two macromolecules that are commonly employed as ocular biomaterials, namely, poly(vinylpyrrolidone) (PVP) and hyaluronan (HA), are compared with two known model glycoproteins, namely bovine submaxillary mucin (BSM) and alpha(1)-acid glycoprotein (AGP), with regard to their nonfouling efficiency, wettability, and tribological properties when freely present in the lubricant, enabling spontaneous adsorption, and when chemisorbed under low contact pressures. Chemisorbed coatings were prepared by means of photochemically triggered nitrene insertion reactions. BSM and AGP provided boundary lubrication when spontaneously adsorbed in a hydrophobic contact with a coefficient of friction (CoF) of similar to 0.03 similar to 0.04. PVP and HA were found to be excellent boundary lubricants when chemisorbed (CoF <= 0.01). Notably, high-molecular-weight PVP generated thick adlayers, typically around 14 nm, and was able to reduce the CoF below 0.005 when slid against a BSM-coated poly(dimethylsiloxane) pin in a tearlike fluid.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据