期刊
BIOCONJUGATE CHEMISTRY
卷 28, 期 5, 页码 1403-1412出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00082
关键词
-
类别
资金
- IdEx Bordeaux
- Centre National de la Recherche Scientifique (CNRS)
- NSF [MSN 1412367, MSN 1545634]
- Universite de Bordeaux
- Bordeaux INP
- GIS Advanced Materials in Aquitaine
- Institut Carnot MIB
- ESF Precision Polymer Materials program [09-RNP-124]
- Direct For Mathematical & Physical Scien [1412367] Funding Source: National Science Foundation
- Division Of Chemistry [1412367] Funding Source: National Science Foundation
We report the synthesis of methionine-containing recombinant elastin-like polypeptides (ELPs) of different lengths that contain periodically spaced methionine residues. These ELPs were chemoselectively alkylated at all methionine residues to give polycationic derivatives. Some of these samples were found to possess solubility transitions in water, where the temperature of these transitions varied with ELP concentration, nature of the methionine alkylating group, and nature of the sulfonium counterions. These studies show that introduction and controlled spacing of methionine sulfonium residues into ELPs can be used as a means both to tune their solubility transition temperatures in water using a variety of different parameters and to introduce new side-chain functionality.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据