4.6 Article

Upconversion fluorescence imaging of HeLa cells using ROS generating SiO2-coated lanthanide-doped NaYF4 nanoconstructs

期刊

RSC ADVANCES
卷 7, 期 48, 页码 30262-30273

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25383k

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资金

  1. EU within the European Regional Development Fund, through the grant Innovative Economy [POIG.01.01.02-00-008/08]
  2. project 'Development of the cluster center of biomedical engineering' implemented under the Economy Operational Program [UDA-POIG.05.01.00-00]
  3. EU Research Project FP7-People-IRSES-BRASINOEU [PIRSES-GA-2012-318916]
  4. European Regional Development Fund within the Innovation Economy Operational Program [POIG.02.02.00-00-025/09]
  5. Swiss National Science Foundation through the Nano-Tera.ch Focused Project (NTF), 'NanoUp'
  6. [PNSC 2013/11/B/NZ1/00089]
  7. [NN UMO-2013/08/A/ST3/00297]
  8. [DEC-2012/07/B/ST5/02080]
  9. [DEC-2014/15/D/ST5/02604]

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Inorganic nanomaterials able to generate reactive oxygen species (ROS) are promising components for modern medical applications. Activated by near-infrared light, up-converting beta-NaYF4 doped with Er3+ - Yb3+ and Tm3+- Yb3+ pair ions nanoparticles (UCNPs), have a wide range of applications in biological imaging as compared to traditional reagents excited by ultra-violet or visible light. We analysed the green-red and the blue-red luminescence to explain the mechanism of the upconversion depended on the surface condition. The influence of SiO2 coating on the cytotoxicity of the as-produced UCNPs towards HeLa cancer cells was reported. We demonstrated a possibility of a direct UCNPs application to photodynamic therapy, without need to attach additional molecules to their surface. The presence of Tm3+ - Yb3+ pair ions, thus ROS generation capability, renders the SiO2 shell coated nanoparticles to become potentially useful theranostic agent.

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