期刊
RSC ADVANCES
卷 7, 期 18, 页码 11149-11157出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25104h
关键词
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资金
- Ministry of Trade, Industry Energy (MOTIE) [10062079, R0005303, R0005237]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014055946]
Here, we report novel thermo-responsive fluorescent nanoparticles of carbonized poly(N-isopropylacrylamide) (PNIPAAm) through two pathways, partial carbonized PNIPAAm (F-PNIPAAm) and full carbonized PNIPAAm (FNP) acid treatment. The carbonized PNIPAAm generated different properties depending on acid treatment time to control the lower critical solution temperature (LCST) behaviors as a biosensor based on a fluorescence on-off system. Furthermore, the FNP-PNIPAAm also showed reversible capability based on fluorescence intensity, with a high fluorescence signal observed at room temperature (25 degrees C) but quenching at physiological temperature (37 degrees C). H-NMR, FT-IR, X-ray dispersion (XRD), and X-ray photoelectron spectroscopy (XPS) confirmed the associated chemical moieties of FNPPNIPAAm and FNP. After confirming the cytotoxicity of the prepared material, we carried out in vitro bioimaging studies using MDAMB, A-549, and MDCK cells by confocal laser-scanning microscopy. Therefore, we successfully established a convenient, rapid, and ecofriendly synthetic approach to the synthesis of FNPs based on PNIPAAm. These FNPs exhibited tunable luminescence properties, high aqueous stability, and low cytotoxicity, suggesting potential applications in bio-labeling, bio-imaging, and optoelectronics.
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