期刊
RSC ADVANCES
卷 7, 期 2, 页码 791-800出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25244c
关键词
-
资金
- Croatian Science Foundation [IP-2013-11-5596]
A combination of flow chemistry and batch-based synthetic procedures has been successfully applied to the assembly of novel 4,5-unsaturated L-ascorbic acid series 6a-6n with diverse C-6-substituted 1,2,3-triazole moiety. We report herein the first Cu(I)-catalyzed 1,3-dipolar cycloaddition of azido functionalized L-ascorbic acid derivative and selected alkynes to provide target 1,2,3-triazolyl appended 4,5-didehydro-5,6-dideoxy-L-ascorbic acid library 6a-6n under both micro-flow and batch conditions. Implementation of ultrasound with flow chemistry accelerated hour-scale reaction conditions in batch to the minute range in micro-flow device and considerably improved the yields for the flow syntheses of 6a-6n. Moreover, the synergistic use of microreactor technology and ultrasonic irradiation highlights the sustainable eco-friendly aspect of utilized method.
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