期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 154, 期 -, 页码 171-177出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.03.004
关键词
Silymarin; Milk thistle; Nanoencapsulation; Solubility; Antimicrobial activity
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1D1A1A01061235]
- National Research Foundation of Korea [2015R1D1A1A01061235] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The aims of this study were to improve the water solubility and antimicrobial activity of milk thistle silymarin by nanoencapsulation and to assess the functions of silymarin nanoparticle-containing film as an antimicrobial food-packaging agent. Silymarin nanoparticles were prepared using water-soluble chitosan (WCS) and poly-gamma-glutamic acid (gamma-PGA). As the WCS and silymarin concentrations increased, particle size and polydispersity index (PDI) significantly increased. Nanoencapsulation significantly improved the water solubility of silymarin 7.7-fold. Antimicrobial activity of silymarin was effectively improved when silymarin was entrapped within the nanocapsule compared to when it was not entrapped. Films incorporating silymarin nanoparticles had better antimicrobial activity than films incorporating free silymarin. The results suggest that silymarin nanoparticles have applications in antimicrobial food additives and food packing. (C) 2017 Elsevier B.V. All rights reserved.
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