期刊
RSC ADVANCES
卷 7, 期 54, 页码 34267-34275出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra03565a
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资金
- Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University [RES560530078AM]
A set of lipidated peptides was in situ synthesised on cotton fabrics using Fmoc-based peptide synthesis. The resulting modified surfaces exhibit highly potent antibacterial activities in two Gram-negative bacteria including Escherichia coli (ATCC 8739) and Pseudomonas aeruginosa (ATCC 9027), along with moderate antibacterial activities in a Gram-positive bacterium Staphylococcus aureus (ATCC 6538P). As anticipated from covalently bound antimicrobial moieties, a representative membrane disintegration assay suggested that the modified surfaces inhibited bacteria by disrupting the integrity of bacterial cell membranes. Without non-natural D-peptides used in previous studies, this new class of non-leaching antibacterial surfaces offer potent activities while having more practical and economical productions. Furthermore, biocompatibility studies suggest that a selected set of surfaces show no toxicity, thus rendering them suitable for biomedical applications.
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