期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 89, 期 -, 页码 966-972出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.02.089
关键词
Coumarin; Chalcone; SERM; Breast cancer; Molecular docking
资金
- Department of Science and Technology (DST), New Delhi [SR/FT/LS-132/2012, SERB/F/4302/2012-13]
By utilizing concept of molecular hybridization, involving combination of various Pharmacophore, novel substituted coumarin-chalcone hybrids was synthesized and evaluated for anti-proliferative activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. In-vivo study was carried out by N-methyl nitrosourea (MNU) induced mammary carcinoma in virgin female Spraque Dawly (SD) rats. The compound 5b has highest potential than standard drug Adriamycin, comparable against Tamoxifen against ER-positive MCF-7 breast cancer cell lines. Docking study was performed to study the binding orientation and affinity of synthesized compounds on the ER-a enzyme. (c) 2017 Elsevier Masson SAS. All rights reserved.
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