期刊
AGING-US
卷 9, 期 4, 页码 1219-1232出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101223
关键词
shelterin; telomere; brain aging; development
资金
- National Natural Science Foundation of China [81000875, 81171846, 81270433, 81372099, 81471400, 81522017, 81671900]
- Shanghai Foundation for Basic Research of Science and Technology, China [13JC1404001]
- Foundation for Committee of Science and Technology in Shanghai [11ZR1422100]
- Shanghai Municipal Education Commission
- Association pour la Recherche sur le Cancer and Fondation de France
- French Government (National Research Agency, ANR) through LABEX SIGNALIFE [ANR-11-LABX-0028-01]
- Fondation ARC
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging.
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