期刊
ANTICANCER RESEARCH
卷 37, 期 6, 页码 3045-3052出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.11659
关键词
Adenoid cystic carcinoma; salivary gland tumor; head and neck cancer; prognosis; metastasis
类别
资金
- Howard Hughes (HHMI) Medical Fellows program
Background: Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with unpredictable growth and poorly understood prognostic factors. Patients and Methods: A database search of patients treated at a single Institution was used to identify patients with histologically-confirmed ACC. Patient, tumor, and treatment characteristics were examined via review of medical records. Results: Overall survival of 70 patients identified at 5, 10, and 15 years was 80.4%, 61.3%, and 29.4%, respectively. Disease recurrence was seen in 31.9%; of these, 72.7% developed distant metastasis. Older age, higher stage, skull base involvement, positive margins, and metastatic disease, but not local recurrence, predicted a worse overall survival. Higher stage and skull base disease were also associated with shorter disease-free survival. While lung metastasis was the most common, vertebral metastasis was associated with poorer survival. Conclusion: Disease stage, positive margins, skull base involvement, perineural invasion, time to recurrence, and location of metastasis, but not nodal involvement, could serve as poor prognostic factors in ACC.
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