期刊
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
卷 56, 期 6, 页码 700-707出版社
AMER THORACIC SOC
DOI: 10.1165/rcmb.2016-0308TR
关键词
phosphoinositide 3-kinase; asthma; bronchodilator; inflammation
资金
- National Institutes of Health [1F31HL134264-01, P01-HL114471-03.]
Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, and shortness of breath. Immune cells and airway structural cells orchestrate asthma pathophysiology, leading to mucus secretion, airway narrowing, and obstruction. Phosphoinositide 3-kinase, a lipid kinase, plays a crucial role in many of the cellular and molecular mechanisms driving asthma pathophysiology and represents an attractive therapeutic target. Here, we summarize the diverse roles of phosphoinositide 3-kinase in the pathogenesis of asthma and discuss novel therapeutic approaches to treatment.
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