期刊
MATERIALS
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ma10040431
关键词
heat-polymerized resin; dimethylaminododecyl methacrylate; Candida albicans biofilms; denture stomatitis; antifungal properties
类别
资金
- International Science and Technology Cooperation Program of China [2014DFE30180]
- National Natural Science Foundation of China [81372889, 81430011, 81372890]
- Youth Grant of the Science and Technology Department of Sichuan Province, China [2017JQ0028]
- Innovative Research Team Program of Sichuan Province
- Scientific Research Starting Foundation [2015SCU11015]
- National Institutes of Health [R01 DE17974]
- University of Maryland School of Dentistry
The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin. The specimens were incubated with C. albicans solution in medium to form biofilms. Then Colony-Forming Units, XTT assay, and scanning electron microscope were used to evaluate antifungal effect of DMADDM-modified resin. DMADDM modified acrylic resin had no effect on the flexural strength, bond quality, and surface roughness, but it increased the surface charge density significantly. Meanwhile, this new resin inhibited the C. albicans biofilm significantly according to the XTT assay and CFU counting. The hyphae in C. albicans biofilm also reduced in DMADDM-containing groups observed by SEM. DMADDM modified acrylic resin was effective in the inhibition of C. albicans biofilm with good physical properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据