期刊
APPLIED SURFACE SCIENCE
卷 416, 期 -, 页码 581-586出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2017.04.106
关键词
Surface enhancement raman spectrum; Mercuric ion; Magnetic substrate; Thymine-Hg2+-thymine
类别
资金
- National Natural Science Foundation of China [51602263]
- Fundamental Research Funds for the Central Universities [XDJK2015C099, SWU114079]
- China Postdoctoral Science Foundation [2015M572427, 2016T90827]
- Chongqing Postdoctoral Research Project [xm2015019]
Mercuric ion (Hg2+) is one toxic metal ion existed in aquatic ecosystems which would seriously damage human central nervous system and other organs. So developing an approach to sensitively detect Hg2+ in our living environment is urgent and important. In this work, a novel surface enhancement Raman spectrum(SERS) sensor is fabricated for high selective and ultrasensitive detection of Hg2+ in aqueous solution, based on a stable thymine-Hg2+- thymine (T-Hg2+-T) structure and the pi-pi interaction between single-stranded DNA (ssDNA) and single walled carbon nanotubes (SWCNTs). Herein, SWCNTs act as Raman labels to produce characteristic Raman peaks which can be a beacon to quantitative detect Hg2+. In the presence of Hg2+, the ssDNA can capture Hg2+ forming T-Hg2+-T structure, which makes SWCNTs leave the hot spots of the SERS-based biosensor. With this design, the Raman intensity of SWCNTs decreased with the increasing concentration of Hg2+. At the same time, CoFe2O4@ Ag as active SERS substrates can effectively enhance sensitivity and uniformity of the biosensor through aggregation by magnet. Under optimal conditions, this proposed biosensor can detect Hg2+ at a range from 1 pM to 100 nM with a detection limit of 0.84 pM. With the advantages of good sensitivity, selectivity, simplicity and rapidity, the biosensor is potentially suitable for monitoring of Hg2+ in environmental applications. (C) 2017 Published by Elsevier B.V.
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