期刊
ADVANCED MATERIALS
卷 29, 期 23, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201605928
关键词
nanotheranostic generators; phototherapy; supramolecular assembly; tumor microenvironment responses
类别
资金
- Major State Basic Research Development Program of China (973 Program) [2013CB733802, 2014CB744503]
- National Natural Science Foundation of China (NSFC) [81422023, 51273165, U1505221]
- Fundamental Research Funds for the Central Universities [20720160065, 20720150141]
- Science Foundation of Fujian Province [2014Y2004, 2016ZY002]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn2+-assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment-triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy. MnO2 nanosheets serve as a highly effective DVDMS carrier and in situ oxygen and nanoDVD generator. In MCF-7 cells and xenograft tumors, MnO2/DVDMS is reduced by glutathione (GSH) and H2O2 and reassembled into nanoDVD, which can be monitored by activated magnetic resonance/fluorescence/photoacoustic signals. Intriguingly, the decrease of GSH, the production of O-2, and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor efficacy in vitro and in vivo, offering a new avenue for cancer theranostics.
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