期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 21, 页码 17799-17806出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b04576
关键词
fluorescence; bioimaging; gold nanoclusters; nucleolus; reverse transformation
资金
- National Natural Science Foundation of China [21373271, 21273287]
- National Key Basic Research Program of China [2012CB518000]
- Natural Science Foundation of Shandong Province [ZR2014BM028]
- Key Technologies R&D Program of Shandong Province [2015GSF118013]
- CSC
Nucleoli are important subnuclear structures inside tells. We report novel fluorescent gold nanoclusters AuNCs) that are able to stain the nucleoli selectively and; make it possible to explore the nucleolar morphology with,fluotes(ence imaging technique. This novel probe is prepared through an easy synthesis method by employing a tripeptide (Lys-Cys-Lys), as the surface ligand. The properties, including deep-red fluorescence emission (680 nm), large Stocks shift, broad excitation band, low tytotoxidty, and good photostability, endow this probe with potential for bioanalytital applitations: Because of their Small size and their positively charged surface,,K-AuNCs are able to accumulate efficiently at the nucleolar regions and provide precise . morphological information. K-AuNCs are also used to-monitor the nuclear dynamics along the reverse-transformation Process:of malignant cells, inauced by the agonist of protein A,8-chloro-cyclic adenosine monophosphate. This gives a novel-approach for investigating the working mechanism of antitumor drugs.
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