期刊
ANTIVIRAL RESEARCH
卷 143, 期 -, 页码 69-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2017.04.004
关键词
HSV-1; vhs/UL41; Ch25h
资金
- National Natural Science Foundation of China [81371795, 81571974]
Cholesterol 25-hydroxylase (Ch25h) is an interferon-inducible protein, and recent studies have demonstrated that it inhibited the replication of many enveloped viruses. However, in this study, we found that cells infected with wild-type (WT) HSV-1 reduced the expression of Ch25h, and ectopic expression of Ch25h could not inhibit the replication of WT-HSV-1. By screening assay, HSV-1 UL41 protein was found to down-regulate the expression of Ch25h. In addition, UL41 abrogated the antiviral activity of Ch25h via degrading its mRNA. Furthermore, ectopic expression of Ch25h inhibited the replication of UL41-null mutant HSV-1 (R2621), but not WT-HSV-1, and knockdown of Ch25h did not affect the replication of WT-HSV-1, but promoted the replication of the R2621. For the first time, HSV-1 UL41 was demonstrated to evade the antiviral function of Ch25h via its endonuclease activity. (C) 2017 Elsevier B.V. All rights reserved.
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