期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 20, 页码 16914-16922出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b03932
关键词
injectability; hydroxyapatite; silk; bone regeneration; biomimetic
资金
- National Basic Research Program of China (973 Program) [2013CB934400]
- Natural Science Foundation of Jiangsu Province [BK20140397, BK20140401]
- second affiliated hospital of Soochow University preponderant clinic discipline group project funding [XKQ2015010]
Injectable hydrogel systems are important bone substitutes for regeneration because of their handling properties and the ability to fill irregular defects. Silk-hydroxyapatite composite materials with silk nanofibers in hydrogels were prepared and used as biomaterials for osteogenesis. These thixotropic silk nanofiber hydrogels and water-dispersible silk-HA nanoparticles were blended to form injectable nanoscale systems with a homogeneous distribution of a high HA content [60% (w/w)] to imitate bone niche. A modulus of similar to 21 kPa was also achieved following the addition of HA in the systems, providing physical cues to induce osteodifferentiation. The composite hydrogels supported improved osteogenesis compared to that with silk nanofiber hydrogels. The newly formed bone tissue and bone defect healing were detected after implantation of the silk-HA composite hydrogels, suggesting utility for the regeneration of irregular bone defects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据