期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 13, 页码 2863-2867出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.04.075
关键词
Isocostunolide; Glioma stem cells; Cell proliferation; Apoptosis; Colony formation
资金
- National Natural Science Foundation of China (NSFC) [81472862, 81225024]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA 01040403]
- Top Talents Program of Yunnan Province, China [2012HA014]
- Yunnan Applied Basic Research Projects [2013FA020]
Glioblastoma multiform (GBM) is a highly aggressive brain tumor with poor life expectancy, and glioma stem cells (GSCs) are a small population of tumor cells existed in GBM, in which GSCs response to drive GBM recurrence, invasion and contribute to the anti-cancer resistance. GSCs have been identified and developed as a therapeutic target for GBM and can be used in drugs screening. Isocostunolide is a natural sesquiterpenoid and contained abundant resource in medicinal plants, but the anti-cancer efficacies of it against GSCs are still unexplored. In this investigation, the anti-tumor activity of isocostunolide against GSCs was investigated and the result demonstrated that it inhibited the growth of GSCs (GSC-3#, GSC-12#, GSC-18#) significantly with an IC50 value of 2.80 mu g/ml, 2.61 mu g/ml, 1.07 mu g/ml, respectively. In further mechanism study, isocostunolide inhibited GSCs cell proliferation, induced GSCs apoptosis significantly, as well as increased the proportion of the cleavage of caspase-3. The result suggested that isocostunolide induced GSCs apoptosis via the caspase dependent apoptotic pathway. Moreover, isocostunolide damaged GSCs colony formation capacity significantly and exhibited the anti-cancer efficacy against GSCs in vitro. (C) 2017 Published by Elsevier Ltd.
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