Altered network efficiency of functional brain networks in patients with breast cancer after chemotherapy

Objective: To investigate the topological organization of functional brain networks in chemotherapy-treated breast cancer (BC) patients with source memory impairment. Methods: Twenty-eight patients with BCfollowingchemotherapyand40age-and education-matched healthy controls (HCs) were recruited in the current study. All participants underwent source memory tests and resting-state functional MRI scans. Individual whole-brain functional brain networks were constructed and analyzed using graph-based network approaches. Results: Compared with the HCs, the BC patients showed lower scores in the source memory tests (P<0.001). Graph-based analyses revealed that the patients showed higher absolute global and local efficiency (both P<0.01) but lower normalized global and normalized local efficiency (both P<0.001) compared with the HCs. Locally, several prefrontal, occipital, and parietal regions exhibited higher nodal efficiency and functional connectivity in the patients(P<0.05, corrected). Finally, positive correlations were observed between normalized global efficiency and Mini-Mental State Examination scores (r=0.398, P=0.036) and between normalized local efficiency and the source memory scores (r=0.497, P=0.01) in the patients. Conclusion: Chemotherapy-treated BC is associated with abnormal organization of large-scale functional brain networks, which could account for source memory dysfunction in patients with BC.