期刊
ONCOTARGET
卷 8, 期 32, 页码 52699-52707出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17084
关键词
TBX2; nasopharyngeal cancer; invasion; proliferation; siRNA
资金
- Youth Foundation of Revitalize and Defend the Key Talent's Subsidy Project from the Science and Education Department of Health and Family Planning of Suzhou [KJXW2015042]
- Jiangsu University Special Program of Medical Science [JLY20160114]
- National Natural Science Foundation of China [81302195, 31371139, 81571282, 81502162]
- Natural Science Foundation of Jiangsu Province [BK20130301]
- National Key Research and Development Program of China [2016YFC1302200]
TBX2 is a member of the T box transcription factor family. Its expression and potential biological functions in nasopharyngeal cancer (NPC) cells are studied here. We showed that TBX2 mRNA and protein expression was significantly elevated in multiple human NPC tissues, as compared with that in adjacent normal tissues. Knockdown of TBX2 by targeted-siRNA significantly inhibited proliferation and invasion of NPC cells (CNE-1 and HONE-1 lines). Meanwhile, TBX2 knockdown also induced G1-phase cell cycle arrest. At the molecular level, we discovered that expressions of several tumor suppressor genes, including p21, p27, phosphatase with tensin homology (PTEN) and E-Cadherin, were increased dramatically after TBX2 knockdown in above NPC cells. Collectively, our results imply that TBX2 overexpression promotes NPC cell proliferation and invasion, possibly via silencing several key tumor suppressor genes.
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