期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 26, 页码 7444-7448出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703279
关键词
cascade reactions; diynes; gold; pyrrolocarbazoles; total synthesis
资金
- JSPS KAKENHI [JP15KT0061, JP24689001]
- Japan Agency for Medical Research and Development (AMED)
- Astellas Foundation for Research on Metabolic Disorders
- Pharmaceutical Society of Japan
- Grants-in-Aid for Scientific Research [15H04654, 15KT0061] Funding Source: KAKEN
In total and formal syntheses of dictyodendrins B, C, E, and F, the key step involved the direct construction of the pyrrolo[2,3-c]carbazole core by the gold-catalyzed annulation of a conjugated diyne with a pyrrole to form three bonds and two aromatic rings. The subsequent introduction of substituents at the C1 (Suzuki-Miyaura coupling), C2 (addition to an aldehyde), N3 (alkylation), and C5 positions (Ullman coupling) provided divergent access to dictyodendrins.
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