期刊
ONCOTARGET
卷 9, 期 1, 页码 958-968出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.22982
关键词
radiation pneumonitis; ERCC1; ERCC2; XRCC1; lung cancer
资金
- National Key Projects of Research and Development of China [2016 YFC 0904600]
- Central Military Commission of the Ministry of Health [16BJZ17]
A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade >= 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade >= 2 RP (CT/TT vs. CC, adjusted HR = 0.517, 95% CI, 0.285-0.939; adjusted P = 0.030). It is the first time demonstrating that CT/TT genotype of ERCC1 354 was significantly associated with lower RP risk after radio therapy.
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