期刊
ONCOTARGET
卷 8, 期 66, 页码 110635-110649出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.22372
关键词
single nucleotide polymorphism; genetic; epigenetic; susceptibility; cancer
资金
- National Science and Technology Support Program [2015BAI13B07]
- National Natural Science Foundation [81772987]
A large number of genes associated with various cancer types contain single nucleotide polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' - and 3' - untranslated regions (UTRs) and affect gene expression by different mechanisms. These mechanisms depend on the role of the genetic elements in which the individual SNPs are located. Moreover, alterations in epigenetic regulation due to gene polymorphisms add to the complexity underlying cancer susceptibility related to SNPs. In this systematic review, we discuss the various genetic and epigenetic mechanisms involved in determining cancer susceptibility related to various SNPs located in different genetic elements. We also discuss the diagnostic potential of these SNPs and the focus for future studies.
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