期刊
ONCOTARGET
卷 8, 期 11, 页码 18021-18030出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14935
关键词
small cell lung cancer; immunotherapy; programmed cell-death ligand 1; stage; overall survival
资金
- National Taiwan University Hospital, Taipei, Taiwan [NTUH 105-S2939, NTUH 106-S3342, NTUH 106-S3343]
Background: Small cell lung cancer (SCLC) is an aggressive malignancy with a distinct natural history and dismal prognosis. SCLC is characterized as a recalcitrant neoplasm with limited therapeutic options and platinum-based chemotherapy is the treatment of choice. Programmed cell death-ligand 1(PD-L1)-mediated immune escape may be a suitable target for specific therapy, but its role in SCLC is unclear. Materials and methods: In total, 186 SCLC cases were investigated. Paraffinembedded tumor sections were stained with a PD-L1 antibody. PD-L1 overexpression was denoted by moderate-to-strong PD-L1 membrane staining in >= 5% of tumor cells. Tumor cells and infiltrating lymphocytes were scored separately. Results: The overall frequency of PD-L1 overexpression, in tumor cells and tumor infiltrating lymphocytes (TILs) was 78.0% and 54.3%, respectively. High tumor PD-L1 expression was significantly correlated with high TIL PD-L1 expression (P=0.001) and stage IV disease (P=0.048). Multivariate analysis revealed that high tumor PD-L1 expression and stage IV disease were two independent risk factors for poor overall survival. Conclusions: High PD-L1 expression was observed in SCLCs compared with their expression in conventional NSCLCs. The aggressive behavior of SCLC could be partially related to PD-L1-mediated immune escape. High PD-L1 expression correlated with poor prognosis and may provide a rationale for immunotherapy for high-grade SCLC.
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