期刊
ONCOTARGET
卷 8, 期 21, 页码 34111-34127出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16292
关键词
brain tumour; cell death; late effects; neuroinflammation; radiotherapy
资金
- Swedish Research Council
- Swedish Childhood Cancer Foundation
- Swedish Cancer Foundation
- Swedish Board of Radiation Safety
- Swedish Brain Foundation
- Gothenburg Medical Society
- Marta and Gunnar V. Philipson Foundation
- Swedish Society of Medicine
- Deutsche Forschungsgemeinschaft [FOR2107, DO 1525/3-1]
Cranial radiotherapy in children typically causes delayed and progressive cognitive dysfunction and there is no effective preventive strategy for radiation-induced cognitive impairments. Here we show that lithium treatment reduced irradiation-induced progenitor cell death in the subgranular zone of the hippocampus, and subsequently ameliorated irradiation-reduced neurogenesis and astrogenesis in the juvenile rat brain. Irradiation-induced memory impairment, motor hyperactivity and anxiety-like behaviour were normalized by lithium treatment. Late-onset irradiation-induced hypopituitarism was prevented by lithium treatment. Additionally, lithium appeared relatively toxic to multiple cultured tumour cell lines, and did not improve viability of radiated DAOY cells in vitro. In summary, our findings demonstrate that lithium can be safely administered to prevent both short- and long-term injury to the juvenile brain caused by ionizing radiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据