期刊
ONCOTARGET
卷 8, 期 46, 页码 81591-81603出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20189
关键词
porphyrin photosensitizers; photodynamic therapy; tumor; application
资金
- National Natural Science Foundation of China [81571833, 81271734, 81000688]
- Heilongjiang Provincial Science Foundation [H2015006]
- Foundation of Science and Technology Innovation Talent of Harbin Science and Technology Bureau [2015RAQXJ100]
- Wu Liande Youth Science Foundation of Harbin Medical University [WLD-QN1104]
- Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province [LBHQ12049]
- National Training Program of Innovation and Entrepreneurship for Undergraduates [201510226011]
- Nn10 plan
- Harbin Medical University Cancer Hospital
In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据